MIRD Projects	Leaders
Active tuberculosis in diabetic patients: biological basis for the increased susceptibility	Margarida Correia-Neves
Ammonium toxicity in yeast: different culture conditions with different nitrogen sources	Cecília Leão
Bovine tuberculosis – One health approach	Margarida Correia-Neves
Computational Molecular Biology and Evolution of the Mycobacterium tuberculosis Complex	Nuno S. Osório
Defining redox pathways in antimalarial drug resistance	Maria Isabel Veiga
Detoxification mechanisms in Plasmodium falciparum malaria	Maria Isabel Veiga
Development of molecular tools in Paracoccidioides brasiliensis: towards identification and characterization of virulent factors	Fernando José Santos Rodrigues
Dynamics of granuloma assembling	Gil Castro
Elucidation of the mechanisms mediating the aging process under caloric restriction	Belém Sampaio-Marques Paula Ludovico
Evaluation of autophagy in cell sheets of adipose stromal/stem cells in normoxia and hypoxia: correlation with stemness	Paula Ludovico
Evaluation of immune-determinants associated with resistance/susceptibility to Paracoccidioides brasiliensis: a mouse model perspective	Fernando José Santos Rodrigues
Evaluation of the effect of diabetic BM stroma on the progression and chemoresistance of AML	Paula Ludovico
Functional impact of allelic variants of metabolic genes under positive selection in the fitness of Mycobacterium tuberculosis	Fernando José Santos Rodrigues
Genetic determinants of malaria resistance in Dominican Republic	Maria Isabel Veiga
Genetic determinants of TB resistance: the IL-12 family of cytokines	Gil Castro
Host pathogen interactions in Mycobacterium ulcerans infection - Buruli Ulcer	Jorge Pedrosa
How the thymus copes with infection?	Margarida Correia-Neves
Immune reconstitution of HIV patients: the role of regulatory T cells and the thymus	Margarida Correia-Neves
Innate immunity & Inflammation: impact on the immune response to intracellular pathogens: (M. tuberculosis; Listeria; Klebsiella)	Gil Castro
Lung development orchestration by tissue macrophages	Sandra Costa
Modulating bacteriostasis in M. tuberculosis infection: impact of the microbiome	Egídio Torrado
Nanomedicine/drug delivery systems to treat mycobacteriosis	Jorge Pedrosa
Pathogen Diversity and Epitope-based Immunoinformatics in Tuberculosis	Nuno S. Osório
Study on the relationship between aging and autophagy in yeast Saccharomyces cerevisiae	Paula Ludovico
The interplay between autophagy and DNA replication stress during aging	Paula Ludovico
The role of LKB1-AMPK pathway on acute myeloid leukemia	Paula Ludovico
Understanding BCG vaccination: Correlates of protection/pathology following infection with M. tuberculosis	Egídio Torrado
Weak acid resistance in yeasts: better food preservative conditions and improvement of Saccharomyces cerevisiae fitness for industrial applications	Cecília Leão

NERD Projects	Leaders
Ataxin-3 and ubiquitin signalling in the nervous system	Patrícia Maciel
Clinical and Genetic studies of human neurodevelopmental disorders	Patrícia Maciel
Communication across the barriers	Fernanda Marques Joana Palha
Exploring the Therapeutic Potential of the Secretome of Mesenchymal Stem Cells in CNS Regenerative Medicine	António Salgado
Hybrid - Templates for Peripheral Nerve Regeneration	António Salgado
Impact of neurotoxicity on fish central nervous system	Armando Almeida Filipa Pinto-Ribeiro
Long term impact of prenatal glucocorticoid exposure (Human study)	Ana João Rodrigues
Maintaining health in old age through homeostasis (Switchbox)	Nuno Sousa
Multidisciplinary Strategies for Spinal Cord Injury Repair	António Salgado
Neural cells modulation and support	João Carlos Sousa
Neuro-Politics: the neural correlates of political decision-making: an fMRI-based approach	Patrício Costa
Pain modulation in chronic pain syndromes and comorbid mood disorders	Armando Almeida Filipa Pinto-Ribeiro
Predictive factors of acute and chronic pain after inguinal hernia repair	Armando Almeida Patrícia JR Pinto
Sensomotor mechanisms and Alzheimer´s disease pathology	Hugo Almeida Ioannis Sotiropoulos
The role of the immune system in mood disorders and cognition	Margarida Correia-Neves

SURD Projects	Leaders
3D Reconstruction of Intestinal Tissue from Capsule Endoscopy Videos by using a Hierarchical Motion Estimation Approach	Carla Rolanda
Biochemical profile and clinical characteristics of patients with suspected deep venous thrombosis and pulmonary thromboembolism	Adhemar Longatto
Development of 3D culture systems for in vitro study of tumour pathophysiology	Fátima Baltazar Marta Viana-Pereira
Esophageal Regeneration by a Biodegradable Fibrous Mesh Implantion after Endoscopic Submucosal Dissection	Carla Rolanda
Lung development orchestration by tissue macrophages	Sandra Costa
Molecularly targeted therapies: mechanisms of resistance	Olga Martinho
Receptor tyrosine kinases (RTKs): signaling, biologic functions, and potential therapeutic targeting in solid tumors	Rui Manuel Vieira Reis
Role of human papillomavirus ( HPV ) in non-small cell lung carcinoma (NSCLC ) .	Adhemar Longatto
Role of Monocarboxylate transporters (MCTs) in cancer	Fátima Baltazar
Soluble guanylyl cyclase (sGC) stimulators and pulmonary hypertension in CDH	Cristina Nogueira-Silva
Study center on prevention and early diagnosis of cancer	Adhemar Longatto
Temporal Control of Cell Differentiation
The role of Human Papilloma Virus ( HPV ) as the etiologic agent of esophageal cancer	Adhemar Longatto
Timing lung branching during development	Rute S Moura
Towards smarter cardiac interventional navigation using MRI-derived personalized models for RT 3D ultrasound interpretation
Ultra-minimally invasive sentinel limph node (SLN) mapping and excisional biopsy	Carla Rolanda

Projects	Leaders
Digital Impression System for Dental Prosthesis	João L. Vilaça
Impact of peripheral neuropathies on CNS function and structure	Armando Almeida Hugo Almeida
Importance of Plasmodium falciparum ABC transporters in antimalarial drug resistance	Maria Isabel Veiga
Innate immunity & Inflammation: impact on the immune response to intracellular pathogens: (M. tuberculosis; Listeria; Klebsiella)
Pathogenesis and Therapeutics of Machado-Joseph disease	Patrícia Maciel
Predictive factors of acute and chronic pain after hysterectomy
Understanding early embryonic T gene – Brachyury - impact in human tumorigenesis	Rui Manuel Vieira Reis