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Name: Nuno S. Osório

Office: I3.09

School Phone: +351 253 604 904

Email: nosorio@med.uminho.pt

 

 

 

Keywords: Evolution Bioinformatics Pathogens Infection Tuberculosis HIV OMICS Biology

About

Nuno S. Osório is an Assistant Investigator at the Life and Health Sciences Research Institute (ICVS), ICVS/3B’s - PT Government Associate Laboratory and Professor at the School of Medicine, University of Minho.

His research interests are the genetic diversity and evolution microorganisms and the understanding at the molecular level of the structural and functional impact on host/pathogen interaction and human disease.

NSO supervises a multidisciplinary team of researchers (for more information visit http://www.evobiomed.com)

Projects

Computational Molecular Biology and Evolution of the Mycobacterium tuberculosis Complex (Leader) 

Pathogen Diversity and Epitope-based Immunoinformatics in Tuberculosis (Leader) 

Functional impact of allelic variants of metabolic genes under positive selection in the fitness of Mycobacterium tuberculosis  

Importance of Plasmodium falciparum ABC transporters in antimalarial drug resistance  

Selected Publications

Osório, Nuno S., Fernando Rodrigues, Sebastien Gagneux, Jorge Pedrosa, Marta Pinto-Carbó, António G. Castro, Douglas Young, Iñaki Comas, and Margarida Saraiva. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic and non-antibiotic related pressure." Molecular Biology and Evolution (2013) 30 (6): 1326-1336. doi: 10.1093/molbev/mst038

Almeida B1, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osório NS, Kollau A, Mayer B, Leão C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. NO-mediated apoptosis in yeast. J Cell Sci. 2007 Sep 15;120(Pt 18):3279-88. Epub 2007 Aug 28.

Almeida B1, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osório NS, Kollau A, Mayer B, Leão C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. NO-mediated apoptosis in yeast. J Cell Sci. 2007 Sep 15;120(Pt 18):3279-88. Epub 2007 Aug 28.

Carvalho A, Osório NS, Saraiva M, Cunha C, Almeida AJ, Teixeira-Coelho M, Ludovico P, Pedrosa J, Pitzurra L, Aversa F, Romani L, Castro AG, Rodrigues F. The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation. PLoS One. 2011;6(11):e28256. doi: 10.1371/journal.pone.0028256. Epub 2011 Nov 23.

Carvalho A, Costa P, Triunfante V, Branca F, Rodrigues F, Santos CL, Correia-Neves M, Saraiva M, Lecour H, Castro AG, Pedrosa J, Osório NS. Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of non-B and -G Subtypes. J Clin Microbiol. 2015 Feb 18. pii: JCM.03611-14.

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