Research & Scientists | People | ASALGADO


Name: António Salgado

Office: G2.31

School Phone: +351 253 604 947

Email: asalgado@med.uminho.pt




Keywords: Regenerative Medicine Stem Cells Secretome Biomaterials Spinal Cord Injury Parkinson's Disease


António Salgado is a biologist and received is PhD in Materials Science and Engineering- TissueEngineering and Hybrid Materials, from the University of Minho in 2005, followed by a post-doc at the University of Toronto and Life and Health Sciences Research Institute (ICVS) at University of Minho, dedicated to CNS regenerative medicine. Currently he is a PrincipaI Investigator at the Life and Health SciencesResearch Institute (ICVS) and an Adjunct Associate Professor in the School of Medicine,University of Minho. His research interests are focused on the development of innovative therapies for CNS repair, namely on Spinal Cord Injury and Parkinson’s Disease. His main areas of research are: 1) Development of ECM like hydrogels for the transplantation of Mesenchymal Stem Cells into the injuredCNS; 2) Role of the secretome of MSCs in neuroprotection and repair, particularly the establishment of novel therapies based on the sole use of MSCs secretome. He is currently an author of more than 80 papers (over 2800citations; h-Index=25), and has delivery over 40 invited talks worldwide. As of September 2017, he has been able to attract near 1.5M€ through competitive calls and contracts with industry. He serves as an Associate Editor for Biomed Research International, Biochimie and BMC Neuroscience. He has received several distinctions for his work including the Gulbenkian Award on Cutting Edge Research in Life Sciences, and the Prize Melo e Castro for SpinalCord Injury Research, awarded by the Santa Casa de Misericórida de Lisboa.

Selected Publications:

L.A.Rocha, D.A. Learmonth, R.A. Sousa, A.J. Salgado. “avß3 and a5ß1 Integrin-Specific Ligands: From Tumour AngiogenesisInhibitors to Vascularization Promotorers in Regenerative Medicine?”. (2017), BiotechnologyAdvances, in press.

A.O. Pires, F.G. Teixeira, B.Mendes-Pinheiro, S.C. Serra, N. Sousa, A.J.Salgado. “Old and New Challenges in Parkinson’s Disease Therapeutics”, (2017),Progress in Neurobiology, (2017), 156: 69-89

L.F. Martins, Rui O. Costa,Joana R. Pedro, P. Aguiar, S.C. Serra, N. Sousa, A.J. Salgado, R.D. Almeida. “Mesenchymal Stem CellsSecretome-Induced Axonal Outgrowth is Mediated by BDNF”, (2017), ScientificReports, (2017), 7(1): 4153

- F.G.Teixeira, M.M. Carvalho, K.M. Panchalingam, A.J. Rodrigues, B. Mendes-Pinheiro,S. Anjo, B. Manadas, L. Behie, N. Sousa, A.J.Salgado. “Impact of the Secretome of Human Mesenchymal Stem Cells on BrainStructure and Animal behavior in a Rat Model of Parkinson’s Disease”, (2017), StemCells Translational Medicine, 6(2): 634-646.

- N.Sevivas, F.G. Teixeira, R. Portugal, L. Araújo, S.C. Serra, L.F. Carriço, N.Ferreira, M.V da Silva, J. Espregueira-Mendes, S. Anjo, B. Manadas, N. Sousa, A.J. Salgado. “Mesenchymal Stem CellsSecretome: A Potential Tool for the Prevention of the Muscle DegenerationChanges Associated to Massive Rotator Cuff Tears”. The American Journal ofSports Medicine, (2017), 45(1): 179-188

E.D. Gomes, S.S. Mendes, H. Leite-Almeida, J.M.Gimble, R.Y. Tam, M.S. Shoichet, N. Sousa, N.A. Silva, A.J. Salgado. “Combination of a Peptide-modified Gellan Gum Hydrogel withCell therapy in a Lumbar Spinal Cord injury Animal Model”. Biomaterials,(2016), 105: 38-51

A.O. Pires, B. Mendes-Pinheiro, F.G. Teixeira,S.I. Anjo, S. Ribeiro-Samy, E.D. Gomes, S.C. Serra, N.A. Silva, B. Manadas, N.Sousa, A.J. Salgado. “Unveiling theDifferences of the Secretome of Human Bone Marrow Mesenchymal Stem Cells,Adipose Tissue Derived Stem Cells and Human Umbilical Cord Perivascular Cells:A Proteomic Analysis”. Stem Cells & Development, (2016), 25(14):1073-1083

A.J. Salgado. “Modulationof the Mesenchymal Stem Cells Secretome Using Computer-Controlled Bioreactors:Impact on Neuronal Cell Proliferation, Survival and Differentiation”. ScientificReports, (2016), 6: 27791 (A.J.Salgado and L.A. Behie share senior authorship).

F.G. Teixeira, M.M. Carvalho, A.Neves-Carvalho, K. M. Panchalingam, L.A. Behie, L. Pinto, N. Sousa, A.J. Salgado. “Secretome ofMesenchymal Progenitors from the Umbilical Cord Acts as Modulator ofNeural/Glial Proliferation and Differentiation”. Stem Cells Reviews andReports. (2015), 11(2): 288-297


Exploring the Therapeutic Potential of the Secretome of Mesenchymal Stem Cells in CNS Regenerative Medicine (Leader) 

Hybrid - Templates for Peripheral Nerve Regeneration (Leader) 

Multidisciplinary Strategies for Spinal Cord Injury Repair (Leader) 

Selected Publications

Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies-A review. Progress in Polymer Science. 2010 Nov; 35(9): 1163-94. doi: 10.1016/j.progpolymsci.2010.04.006

Silva NA, Sousa N, Reis RL, Salgado AJ. From Basics to Clinical: A Comprehensive Review on Spinal Cord Injury. Prog Neurobiol, 114:25-57 (2014).

Haastert-Talini K, Geuna S., Dahlin LB, Meyer C, Stenberg S, Freier T, Heimann H., Barwig C, Pinto LFV, Raimondo S, Gambarotta G., Ribeiro Samy S, Sousa N, Salgado AJ, Ratzka A, Wrobel S, Grothe C. Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials, 34(38):9886-904 (2013).

Silva NA, Cooke MJ, Tam RY, Sousa N, Salgado AJ, Reis RL, Shoichet MS. The effects of peptide modified gellan gum and olfactory ensheathing glia cells on neural stem/progenitor cell fate. Biomaterials. 2012 Sep;33(27):6345-54. doi: 10.1016/j.biomaterials.2012.05.050. Epub 2012 Jun 12.

Teixeira FG, Carvalho MM, Sousa N, Salgado AJ. Mesenchymal Stem Cells Secretome: a new paradigm for Central Nervous System Regeneration? Cell Mol Life Sci. 2013 Oct;70(20):3871-82. doi: 10.1007/s00018-013-1290-8. Epub 2013 Mar 1.

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