Research & Scientists | Neurosciences | Selected Publications

NeuroSciences Selected Publications


Alves ND, Patrício P, Correia JS, Mateus-Pinheiro A, Machado-Santos AR, Loureiro-Campos E, Morais M, Bessa JM, Sousa N, Pinto L. Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus. Brain Structure and Function 223(1):415-428 (2018)

Cerqueira JJ, Compston DAS, Geraldes R, Rosa MM, Schmierer K, Thompson A, Tinelli M, Palace J. Time matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis?. Journal of Neurology, Neurosurgery and Psychiatry 89(8):844-850 (2018)

Coimbra B, Soares-Cunha C, Borges S, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits. eLife 6:e25843 (2018)

Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P. Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3. Movement Disorders 33(5):815-826 (2018)

Esteves M, Magalhães R, Marques P, Castanho TC, Portugal-Nunes C, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory. Frontiers in Aging Neuroscience 10:58 (2018)

Esteves S, Oliveira S, Duarte-Silva S, Cunha-Garcia D, Teixeira-Castro A, Maciel P. Preclinical evidence supporting early initiation of citalopram treatment in Machado-Joseph disease. Molecular Neurobiology (2018) [Epub ahead of print]

Ferreira AC, Santos T, Sampaio-Marques B, Novais A, Mesquita SD, Ludovico P, Bernardino L, Correia-Neves M, Sousa N, Palha JA, Sousa JC, Marques F. Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours. Molecular Psychiatry 23(4):1031-1039 (2018)

Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ. Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair. Stem Cells 36(5):696-708 (2018)

Gonçalves CS, Vieira de Castro J, Pojo M, Martins EP, Queirós S, Chautard E, Taipa R, Pires MM, Pinto AA, Pardal F, Custódia C, Faria CC, Clara C, Reis RM, Sousa N, Costa BM. WNT6 is a Novel Oncogenic Prognostic Biomarker in Human Glioblastoma. Theranostics 8(17):4805-4823 (2018)

Magalhães R, Barrière DA, Novais A, Marques F, Marques P, Cerqueira J, Sousa JC, Cachia A, Boumezbeur F, Bottlaender M, Jay TM, Mériaux S, Sousa N. The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome. Molecular Psychiatry (2018) [Epub ahead of print]

Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF. Disruption of the β1L isoform of GABP reverses glioblastoma replicative immortality in a TERT promoter mutation-dependent manner. Cancer Cell 34(3):513-528 (2018)

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nature Communications 9:291 (2018)

Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G. Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum. The Journal of Physiology 596(16):3695-3707 (2018)

Pinto PR, McIntyre T, Araújo-Soares V, Almeida A, Costa P. Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic post-surgical pain. Pain 159(5):956-967 (2018)

Pinto PR, Paredes AC, Moreira P, Fernandes S, Lopes M, Carvalho M, Almeida A. Emotional distress in haemophilia: Factors associated with the presence of anxiety and depression symptoms among adults. Haemophilia 24(5):e344-e353 (2018)

Puga S, Cardoso V, Pinto-Ribeiro F, Pacheco M, Almeida A, Pereira P. Brain morphometric profiles and their seasonal modulation in fish (Liza aurata) inhabiting a mercury contaminated estuary. Environmental Pollution 237:318-328 (2018)

Taipa R, Ferreira V, Brochado P, Robinson A, Reis I, Marques F, Mann DM, Melo-Pires M, Sousa N. Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and Applied Neurobiology 44(3):298-313 (2018)

Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO Journal 37(20):e99084 (2018)

Vieira N, Bessa C, Rodrigues AJ, Marques P, Chan FY, de Carvalho AX, Correia-Neves M, Sousa N. Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans. Cellular and Molecular Life Sciences 75(11):2027-2044 (2018)


Batista AFR, Martinez JC, Hengst U. Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals. Cell Reports 20(13):3085-3098 (2017)

Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM, Oliveira JF, Ambrósio AF, Sousa N, Cunha RA, Rodrigues AJ, Pinto L, Gomes CA. Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety. Molecular Psychiatry 22(7):1035-1043 (2017)

Coimbra B, Soares-Cunha C, Borges S, Vasconcelos NAP, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid triggered reward deficits. eLIFE 6:e25843 (2017)

Dioli C, Patrício P, Trindade R, Pinto LG, Silva JM, Morais M, Ferreiro E, Borges S, Mateus-Pinheiro A, Rodrigues AJ, Sousa N, Bessa JM, Pinto L, Sotiropoulos I. Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular Psychiatry 22(8):1110-1118 (2017)

Esteves M, Marques P, Magalhães R, Castanho TC, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Structural laterality is associated with cognitive and mood outcomes: An assessment of 105 healthy aged volunteers. Neuroimage 153:86-96 (2017)

Esteves S, Duarte-Silva S, Maciel P. Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts. Medicinal Research Reviews 37(4):860-906 (2017)

Leroy F, Brann DH, Meira T, Siegelbaum SA. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95(5):1089-1102.e5 (2017)

Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Maccarrone G, Almeida OFX, Turck CW, Sousa N, Sotiropoulos I, Filiou MD. Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria. Cerebral Cortex 27(4):2580-2591 (2017)

Machado DR, Afonso DJ, Kenny AR, Öztu Rk-Çolak A, Moscato EH, Mainwaring B, Kayser M, Koh K. Identification of octopaminergic neurons that modulate sleep suppression by male sex drive. eLIFE 6:e23130 (2017)

Mackay A, Burford A, (...) Reis RM, (…) Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell 32(4):520-537.e5 (2017)

Mateus-Pinheiro A, Alves ND, Patricio P, Machado-Santos AR, Campos E, Silva J, Sardinha V, Reis, J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L. AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior. Molecular Psychiatry 22(12):1725-1734 (2017)

Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nature Reviews Neuroscience 18(3):147-157 (2017)

Monteiro S, Roque S, Marques F, Correia-Neves M, Cerqueira JJ. Brain interference: Revisiting the role of IFNγ in the central nervous system. Progress in Neurobiology 156:149-163 (2017)

Pinto V, Sousa P, Catarino SO, Correia-Neves M, Minas G. Microfluidic immunosensor for rapid and highly-sensitive salivary cortisol quantification. Biosensors & Bioelectronics 90:308-313 (2017)

Pires AO, Teixeira FG, Mendes-Pinheiro B, Serra SC, Sousa N, Salgado AJ. Old and new challenges in Parkinson's disease therapeutics. Progress in Neurobiology 156:69-89 (2017)

Santos CR, Duarte AC, Quintela T, Tomás J, Albuquerque T, Marques F, Palha JA, Gonçalves I. The choroid plexus as a sex hormone target: Functional implications. Frontiers in Neuroendocrinology 44:103-121 (2017)

Sardinha VM, Guerra-Gomes S, Caetano I, Tavares G, Martins M, Reis JS, Correia JS, Teixeira-Castro A, Pinto L, Sousa N, Oliveira JF. Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function. Glia 65(12):1944-1960 (2017)

Sevivas N, Teixeira FG, Portugal R, Araújo L, Carriço LF, Ferreira N, Vieira da Silva M, Espregueira-Mendes J, Anjo S, Manadas B, Sousa N, Salgado AJ. Mesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated With Chronic Rotator Cuff Tears. American Journal of Sports Medicine 45(1):179-188 (2017)

Silva A, Almeida B, Fraga JS, Taboada P, Martins PM, Macedo-Ribeiro S. Distribution of amyloid-like and oligomeric species from protein aggregation kinetics. Angewandte Chemie - International Edition 56(45):14042-14045 (2017)

Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons. Journal of Neuroscience 37(34):8256-8272 (2017)


Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Molecular Neurobiology 53(6):3976-3991 (2016)

Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, Caravina GA, Matsushita MM, Clara C, Neder L, Viana-Pereira M, Honavar M, Castro L, Lopes JM, Carvalho B, Vaz R, Máximo V, Soares P, Sobrinho-Simões M, Reis RM, Lima J. The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism. International Journal of Cancer 139(2):414-423 (2016)

Carvalho AF, Reyes BA, Ramalhosa F, Sousa N, Van Bockstaele EJ. Repeated administration of a synthetic cannabinoid receptor agonist differentially affects cortical and accumbal neuronal morphology in adolescent and adult rats. Brain Structure & Function 221(1):407-419 (2016)

Gomes ED, Mendes SS, Leite-Almeida H, Gimble JM, Tam RY, Shoichet MS, Sousa N, Silva NA, Salgado AJ. Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model. Biomaterials 105:38-51 (2016)

Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B, Henderson CE. Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth. Cell Reports 16(2):545-558 (2016)

Lopes F, Barbosa M, Ameur A, Soares G, de Sá J, Dias AI, Oliveira G, Cabral P, Temudo T, Calado E, Cruz IF, Vieira JP, Oliveira R, Esteves S, Sauer S, Jonasson I, Syvanen AC, Gyllensten U, Pinto D, Maciel P. Identification of novel genetic causes of Rett syndrome-like phenotypes. Journal of Medical Genetics 53(3):190-199 (2016)

Lopes S, Lopes A, Pinto V, Guimarães MR, Sardinha MR, Duarte-Silva S, Pinheiro S, Pizarro J, Oliveira JF, Sousa N, Leite-Almeida H, Sotiropoulos I. Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment. Aging Cell 15(2):208-216 (2016)

Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch  M, Almeida OFX, Sousa N, Sotiropoulos I. Tau protein is essential for stress-induced brain pathology. Proceedings of the National Academy of Sciences of the United States of America 113(26):E3755-E3763 (2016)

Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neuroscience and Biobehavioral Reviews 68:547-562 (2016)

Monteiro S, Ferreira FM, Pinto V, Roque S, Sá-Calçada D, Morais M, Sousa N, Correia-Neves M, Cerqueira JJ. Absence of IFNg promotes hippocampal plasticity and enhances cognitive performance. Translational Psychiatry 6:e707 (2016)

Moreira PS, Marques P, Magalhães R. Identifying Functional Subdivisions in the Medial Frontal Cortex. Journal of Neuroscience 36(44):11168-11170 (2016)

Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. The impact of chronic stress on the rat brain lipidome. Molecular Psychiatry 21(1):80-88 (2016)

Pinheiro S, Silva J, Mota C, Vaz-Silva J, Veloso A, Pinto V, Sousa N, Cerqueira J, Sotiropoulos I. Tau mislocation in glucocorticoid-triggered hippocampal pathology. Molecular Neurobiology 53(7):4745-4753 (2016)

Soares-Cunha C, Coimbra B, David-Pereira A, Borges S, Pinto L, Costa P, Sousa N, Rodrigues AJ. Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Nature Communications 7:11829 (2016)

Soares-Cunha C, Coimbra B, Sousa N, Rodrigues AJ. Reappraising striatal D1- and D2-neurons in reward and aversion. Neuroscience and Biobehavioral Reviews 68:370-386 (2016)

Sousa N. The dynamics of the stress neuromatrix. Molecular Psychiatry 21(3):302-312 (2016)

Teixeira FG, Panchalingam KM, Assunção-Silva R, Serra SC, Mendes-Pinheiro B, Patrício P, Jung S, Anjo SI, Manadas B, Pinto L, Sousa N, Behie LA, Salgado AJ. Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation. Scientific Reports 6:27791 (2016)

Teixeira FG, Vasconcelos NL, Gomes ED, Marques F, Sousa JC, Sousa N, Silva NA, Assunção-Silva R, Lima R, Salgado AJ. Bioengineered cell culture systems of central nervous system injury and disease. Drug Discov Today 21(9):1456-1463 (2016)

Torres F, Barbosa M, Maciel P. Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications. Journal of Medical Genetics 53(2):73-90 (2016)


Afonso DJS, Liu D, Machado DR, Pan H, Jepson JEC, Rogulja D, Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Current Biology 25(13):1717-1726 (2015)

Aslani S, Vieira N, Marques F, Costa PS, Sousa N, Palha JA. The effect of high fat diet on rat’s mood, feeding behavior and response to stress. Translational Psychiatry 5:e684 (2015)

Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OFX, Spengler D. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics 10(3):247-257 (2015)

Chatterjee A, Saha S, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Chakraborty A, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar P, Hazra TK. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis. PLOS Genetics 11(1):e1004749 (2015)

Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM. Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas. Oncotarget 6(3):1422-1434 (2015)

Ferreira AC, Mesquita SD, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. From the periphery to the brain: lipocalin-2, a friend or foe? Progress in Neurobiology 131:120-136 (2015)

Gao R, Liu Y, Silva-Fernandes A, Paulucci-Holthauzen A, Chatterjee A, Zhang H, Mattsura T, Fang X, Choudhary S, Ashizawa T, Koeppen A, Maciel P, Hazra TK, Sarkar PS. Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. PLOS Genetics 11(1):e1004834 (2015)

Gonçalves OF, Soares JM, Carvalho S, Leite J, Ganho A, Fernandes-Gonçalves A, Frank B, Pocinho F, Relvas J, Carracedo A, Sampaio A. Brain activation of the defensive and appetitive survival systems in obsessive compulsive disorder. Brain Imaging and Behavior 9(2):255-263 (2015)

Marques P, Soares JM, Magalhães R, Santos NC, Sousa N. The bounds of education in the human brain connectome. Scientific Reports 5:12812 (2015)

Melo A, Kokras N, Dalla C, Ferreira C, Ventura-Silva AP, Sousa N, Pêgo JM. The positive effect on ketamine as a priming adjuvant in antidepressant treatment. Translational Psychiatry 5:e573 (2015)

Mesquita SD, Ferreira AC, Gao F, Coppola G, Geschwind DH, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's Disease. Brain Behavior and Immunity 49:280-292 (2015)

Miranda AM, Oliveira TG. Lipids under stress - a lipidomic approach for the study of mood disorders. Bioessays 37(11):1226-1235 (2015)

Neves-Carvalho A, Logarinho E, Freitas A, Duarte-Silva S, Costa MC, Silva-Fernandes A, Martins M, Cravino Serra S, Lopes A, Paulson HL, Heutink P, Relvas JB, Maciel P. Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells. Human Molecular Genetics 24(1):100-117 (2015)

Oliveira J, Sardinha V, Guerra-Gomes S, Araque A, Sousa N. Do stars govern our actions? Astrocyte involvement in rodents’ behavior. Trends in Neurosciences 38(9):535-549 (2015)

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM, Almeida OF, Sousa N, Pinto L. Differential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus. Neuropsychopharmacology 40(2):338-349 (2015)

Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Brain Structure & Function 220(2):1205-1212 (2015)

Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C. Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication. Epigenetics 10(11):1033-1043 (2015)

Pojo M, Gonçalves CS, Xavier-Magalhães A, Oliveira AI, Gonçalves T, Correia S, Rodrigues AJ, Costa S, Pinto L, Pinto AA, Lopes JM, Reis RM, Rocha M, Sousa N, Costa BM. A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide. Oncotarget 6(10):7657-7674 (2015)

Raposo M, Bettencourt C, Gao F, Ramos A, Kazachkova N, Vasconcelos J, Kay T, Rodrigues AJ, Maciel P, Bettencourt B, Bruges-Armas J, Geschwind D, Coppola G, Lima M. Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease (MJD/SCA3). Movement Disorders 30(7):968-975 (2015)

Teixeira-Castro A, Jalles AL, Esteves S, Kang S, Santos L, Silva-Fernandes A, Neto M, Brielmann RM, Bessa C, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silvermann RB, Oliveira P, Morimoto RI, Maciel P. Serotonergic signalling suppresses ataxin-3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain 138(Pt 11):3221-3237 (2015)


Campanella NC, Berardinelli GR, Scapulatempo-Neto C, Viana D, Palmero E, Pereira R, Reis RM. Optimization of a Pentaplex Panel for MicroSatellite Instability (MSI) Analysis Without Control DNA in a Brazilian Population: Correlation with Ancestry Markers. European Journal of Human Genetics 22(7):875-880 (2014)

Castelhano-Carlos M, Costa PS, Russig H, Sousa N. PhenoWorld: a new paradigm to screen rodent behavior. Translational Psychiatry 4:e399 (2014)

da Glória VG, Martins de Araújo M, Mafalda Santos A, Leal R, de Almeida SF, Carmo AM, Moreira A. T Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1. Journal of Immunology 193(1):391-399 (2014)

Harb MR, Almeida OF. Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior. Translational Psychiatry 4(4):e387 (2014)

Herbert A, Cruickshank JK, Laurent S, Boutouyrie P. Reference Values for Arterial Measurements Collaboration. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal 35(44):3122-3133 (2014)

Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A, Cho K. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical Transactions of the Royal Society B-Biological Sciences 369(1633):20130144 (2014)

Lima A, Sardinha VM, Oliveira AF, Reis M, Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF. Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats. Molecular Psychiatry 19(7):834-841 (2014)

Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica 127(1):109-135 (2014)

Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L. The Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents. Frontiers in Behavioral Neuroscience 8:74 (2014)

Mesquita SD, Ferreira AC, Falcao AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid beta. Cell Death and Differentiation 21(10):1588-1599 (2014)

Opal MD, Klenotich SC, Morais M, Bessa J, Winkle J, Doukas D, Kay LJ, Sousa N, Dulawa SM. Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Molecular Psychiatry 19(10):1106-1114 (2014)

Pandey JP, Kaur N, Costa S, Amorim J, Nabico R, Linhares P, Vaz R, Viana-Pereira M, Reis RM. Immunoglobulin genes implicated in glioma risk. OncoImmunology 3(5):e28609 (2014)

Patchev AV, Rodrigues AJ, Sousa N, Spengler D, Almeida OF. The future is now: early life events preset adult behavior. Acta Physiologica 210(1):46-57 (2014)

Pinto P, McIntyre T, Araujo-Soares V, Ferro R, Almeida A. The role of pain catastrophizing in the provision of rescue analgesia by health care providers following major joint arthroplasty. Pain Physician 17(6):515-524 (2014)

Sampaio A, Soares JM, Coutinho J, Sousa N, Gonçalves ÓF. The Big Five default brain: functional evidence. Brain Structure and Function 219(6):1913-1922 (2014)

Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V. Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Human Molecular Genetics 23(24):6481-6494 (2014)

Silva NA, Sousa N, Reis RL, Salgado AJ. From basics to clinical: A comprehensive review on spinal cord injury. Progress in Neurobiology 114:25-57 (2014)

Soares-Cunha C, Coimbra B, Borges S, Carvalho MM, Rodrigues AJ, Sousa N. The motivational drive to natural rewards is modulated by prenatal glucocorticoid exposure. Translational Psychiatry 4:e397 (2014)

Sotiropoulos I, Lopes AT, Pinto V, Lopes S, Carlos S, Duarte-Silva S, Neves-Carvalho A, Pinto-Ribeiro F, Pinheiro S, Fernandes R, Almeida A, Sousa N, Leite-Almeida H. Selective impact of Tau loss on nociceptive primary afferents and pain sensation.  Experimental Neurology 261:486-493 (2014)

Wrobel S, Serra SC, Ribeiro-Samy S, Sousa N, Heimann C, Barwig C, Grothe C, Salgado AJ, Haastert-Talini K. In Vitro Evaluation of Cell-Seeded Chitosan Films for Peripheral Nerve Tissue Engineering. Tissue Engineering Part A 20(17-18):2339–2349 (2014)


Andrade EB, Alves J, Madureira P, Oliveira L, Ribeiro A, Cordeiro-da-Silva A, Correia-Neves M, Trieu-Cuot P, Ferreira P. TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. Journal of Immunology 191(9):4759-4768 (2013)

Batalha VL, Pego JM, Fontinha BM, Costenla AR, Valadas JS, Baqi Y, Radjainia H, Müller CE, Sebastião AM, Lopes LV. Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Molecular Psychiatry 18(3):320-331 (2013)

Borges S, Coimbra B, Soares-Cunha C, Pego JM, Sousa N, Rodrigues AJ. Dopaminergic modulation of affective and social deficits induced by prenatal glucocorticoid exposure. Neuropsychopharmacology 38(10):2068-2079 (2013)

Cerqueira SR, Oliveira JM, Silva NA, Leite-Almeida H, Ribeiro-Samy S, Almeida A, Mano JF, Sousa N, Salgado AJ, Reis RL. Microglia Response and In vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury. Small 9(5):738-749 (2013)

Haastert-Talini K, Geuna S., Dahlin LB, Meyer C, Stenberg S, Freier T, Heimann H., Barwig C, Pinto LFV, Raimondo S, Gambarotta G., Ribeiro Samy S, Sousa N, Salgado AJ, Ratzka A, Wrobel S, Grothe C. Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 34(38):9886-9904 (2013)

Mateus-Pinheiro A, Patricio P, Bessa J, Sousa N, Pinto L. Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression. Molecular Psychiatry 18(7):748-750 (2013)

Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F. Monocarboxylate transporters (MCTs) in gliomas: Expression and exploitation as therapeutic targets. Neuro-Oncology 15(2):172-188 (2013)

Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar M, Pinheiro C, Pires M, Lopes JM, Jones C, Costello JF, Paredes J, Reis RM, Jordan P. Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Human Molecular Genetics 22(1):84-95 (2013)

Nóbrega C, Nunes-Alves C, Cerqueira-Rodrigues B, Roque S, Barreira-Silva P, Behar SM, Correia-Neves M. T Cells Home to the Thymus and Control Infection. Journal of Immunology 190(4):1646-1658 (2013)

Nunes-Alves C, Nobrega C, Behar SM, Correia-Neves M. Tolerance has its limits: how the thymus copes with infection. Trends in Immunology 34(10):502-510 (2013)

Pereira VH, Cerqueira JJ, Palha JA, Sousa N. Stressed brain, diseased heart: A review on the pathophysiologic mechanisms of neurocardiology. International Journal of Cardiology 166(1):30-37 (2013)

Sampaio A, Bouix S, Sousa N, Vasconcelos C, Férnandez M, Shenton ME, Gonçalves OF. Morphometry of corpus callosum in Williams syndrome: shape as an index of neural development. Brain Structure & Function 218(3):711-720 (2013)

Teixeira FG, Carvalho MM, Sousa N, Salgado AJ. Mesenchymal Stem Cells Secretome: a new paradigm for Central Nervous System Regeneration? Cellular and Molecular Life Sciences 70(20):3871-3882 (2013)

Vinagre J, Almeida A, Populo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, Melo M, Rocha A, Preto A, Castro P, Castro P, Pardal F, Lopes JM, Lara Santos L, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V, Soares P. Frequency of TERT promoter mutations in human cancers. Nature Communications 4:2185 (2013)


Baptista M, Duarte C and Maciel P. Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool. Cellular and Molecular Life Sciences 69(16):2691-2715 (2012)

Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. Journal of Biological Chemistry 287(4):2678-2688 (2012)

Falcao AM, Marques F, Novais A, Sousa N, Palha JA, Sousa JC. The path from the choroid plexus to the subventricular zone: go with the flow! Frontiers in Cellular Neuroscience 6:34 (2012)

Falcao AM, Palha JA, Ferreira AC, Marques F, Sousa N, Sousa JC. Topographical analysis of the subependymal zone neurogenic niche. PLOS One 7(6):e38647 (2012)

Leite-Almeida H, Cerqueira JJ, Wei H, Ribeiro-Costa N, Anjos-Martins H, Sousa N, Pertovaara A, Almeida A. Differential effects of left/right neuropathy on rats' anxiety and cognitive behavior. Pain 153(11):2218-2225 (2012)

Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH, Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N, Correia-Neves M, Palha JA. Lipocalin 2 is present in the EAE brain and is modulated by natalizumab. Frontiers In Cellular Neuroscience 6:33 (2012)

Martinho 0, Granja S, Jaraquemada T, Caeiro C, Miranda-Gonçalves V, Honavar M, Costa P, Damasceno M, Rosner MR, Lopes JM, Reis RM. Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas. PLOS One 7(1):e30769 (2012)

Mesquita SD, Ferreira AC, Sousa JC, Santos NC, Correia-Neves M, Sousa N, Palha JA, Marques F. Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus. Frontiers In Cellular Neuroscience 6:25 (2012)

Palha JA, Santos NC, Marques F, Sousa JC, Bessa JM, Miguelote RF, Sousa N, Belmonte de Abreu P. Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia. Frontiers In Cellular Neuroscience 6:31 (2012)

Pinto PR, McIntyre T, Almeida A, Araujo-Soares V. The mediating role of pain catastrophizing in the relationship between presurgical anxiety and acute postsurgical pain after hysterectomy. Pain 153(1):218-226 (2012)

Pinto PR, McIntyre T, Almeida A, Araujo-Soares V. Understanding pre-surgical predictors of acute pain experience following hysterectomy for benign causes: conceptual and methodological issues. Pain 153(9):1974-197(2012)

Pinto PR, McIntyre T, Nogueira-Silva C, Almeida A, Araujo-Soares V. Risk factors for persistent postsurgical pain in women undergoing hysterectomy due to benign causes: a prospective predictive study. Journal of Pain 13(11):1045-1057 (2012)

Rodrigues AJ, Lea.a P, Pego JM, Cardona D, Carvalho MM, Oliveira M, Costa BM, Carvalho AF, Morgado P, Araujo D, Palha JA, Almeida OF, Sousa N. Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids. Molecular Psychiatry 17(12):1295-1305 (2012)

Silva NA, Cooke MJ, Tam RY, Sousa N, Salgado AJ, Reis AL, Shoichet MS. The Effects of Peptide Modified Gellan Gum and Olfactory Ensheathing Glia Cells on Neural Stem/Progenitor Cell Fate. Biomaterials 33(27):6345-6354 (2012)

Sousa N, Almeida OFX. Disconnection and reconnection: the morphological basis of (mal)adaptation to stress. Trends in Neurosciences 35(12):742-751 (2012)

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