Research & Scientists | Microbiology & Infection | Selected Publications

Microbiology & Infection Selected Publications


Bastos HN, Osório NS, Gagneux S, Comas I, Saraiva M. The troika host- pathogen- extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes. Frontiers in Immunology 8:1948 (2018)

Campos CF, van de Veerdonk FL, Gonçalves SM, Cunha C, Netea MG, Carvalho A. Host genetic signatures of susceptibility to fungal disease. Current Topics in Microbiology and Immunology (2018) [Epub ahead of print]

Cardoso A, Gil Castro A, Martins AC, Carriche GM, Murigneux V, Castro I, Cumano A, Vieira P, Saraiva M. The dynamics of Interleukin-10-afforded protection during Dextran Sulfate Sodium -induced colitis. Frontiers in Immunology 9:400 (2018)

Carmona-Gutierrez D, Bauer MA (…), Ludovico P, (…), Kroemer G, Madeo F. Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell 5(1):4-31 (2018)

Cruz M, Sánchez IM, Diaz J, Cuevas F, Silva M, Disla M, Ferreira PE, Veiga MI. Dosage of single low-dose primaquine to stop malaria transmission. Journal of Infectious Diseases 217(11):1849-1850 (2018)

Cunha C, Carvalho A. Toward the identification of a genetic risk signature for pulmonary aspergillosis in chronic obstructive pulmonary disease. Clinical Infectious Diseases 66(7):1153-1154 (2018)

Gaifem J, Gonçalves LG, Dinis-Oliveira RJ, Cunha C, Carvalho A, Torrado E, Rodrigues F, Saraiva M, Castro AG, Silvestre R. L-threonine supplementation during colitis onset delays disease recovery. Frontiers in Physiology 9:1247 (2018)

Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Subbarao Malireddi RK, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, de Jong DJ, Lacerda JF, Campos A Jr, Melchers W, Lagrou K, Maertens J, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL. Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nature Communications 9:2636 (2018)

Inoue J, Silva M, Fofana B, Sanogo K, Mårtensson A, Sagara I, Björkman A, Veiga MI, Ferreira PE, Djimde A, Gil JP. Plasmodium falciparum Plasmepsin 2 Duplications, West Africa. Emerging Infectious Diseases 24(8):1591-1593 (2018)

Kyrmizi I, Ferreira H, Carvalho A, Figueroa JAL, Zarmpas P, Cunha C, Akoumianaki T, Stylianou K, Deepe GS Jr, Samonis G, Lacerda JF, Campos A Jr, Kontoyiannis DP, Mihalopoulos N, Kwon-Chung KJ, El-Benna J, Valsecchi I, Beauvais A, Brakhage AA, Neves NM, Latge JP, Chamilos G. Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nature Microbiology 3(7):791-803 (2018)

Laforge M, Silvestre R, Rodrigues V, Garibal J, Campillo-Gimenez L, Mouhamad S, Monceaux V, Cumont MC, Rabezanaha H, Pruvost A, Cordeiro-da-Silva A, Hurtrel B, Silvestri G, Senik A, Estaquier J. The anti-caspase inhibitor Q-VD-OPH prevents Aids disease progression in SIV-infected rhesus macaques. Journal of Clinical Investigation 128(4):1627-1640 (2018)

Lima AC, Cunha C, Carvalho A, Ferreira H, Neves NM. Interleukin-6 neutralization by antibodies immobilized at the surface of polymeric nanoparticles as a therapeutic strategy for arthritic diseases. ACS Applied Materials & Interfaces 10(16):13839-13850 (2018)

Mesquita I, Ferreira C, Barbosa AM, Ferreira C, Moreira D, Carvalho A, Cunha C, Rodrigues F, Dinis-Oliveira RJ, Estaquier J, Castro AG, Torrado E, Silvestre R. The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis. Cytokine (2018) [Epub ahead of print]

Miranda MS, Rodrigues MT, Domingues RMA, Costa RR, Paz E, Rodríguez‐Abreu C, Freitas P, Almeida BG, Carvalho MA, Gonçalves C, Ferreira CM, Torrado E, Reis RL, Pedrosa J, Gomes ME. Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery. Advanced Healthcare Materials 7(15):e1800124 (2018)

Miranda MS, Rodrigues MT, Domingues RMA, Torrado E, Reis RL, Pedrosa J, Gomes ME. Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery. Materials Science & Engineering C-Materials for Biological Applications 93:1090-1103 (2018)

Moreira D, Estaquier J, Cordeiro-da-Silva A, Silvestre R. Evaluating the Role of Host AMPK in Leishmania Burden. Methods in Molecular Biology 732:551-563 (2018)

Oliveira-Pacheco J, Alves R, Costa-Barbosa A, Cerqueira-Rodrigues B, Pereira-Silva P, Paiva S, Silva S, Henriques M, Pais C, Sampaio P. The Role of Candida albicans Transcription Factor RLM1 in Response to Carbon Adaptation. Frontiers in Microbiology 9:1127 (2018)

Pereira O, Teixeira A, Sampaio-Marques B, Castro I, Girão H, Ludovico P. Signaling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukemia cells. Journal of Cellular and Molecular Medicine 22(10):4807-4817 (2018)

Pontes O, Costa M, Santos F, Sampaio-Marques B, Dias T, Ludovico P, Baltazar F, Proença F. Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment. European Journal of Medicinal Chemistry 157:101-114 (2018)

Ruesen C, Chaidir L, van Laarhoven A, Dian S, Ganiem AR, Nebenzahl-Guimaraes H, Huynen MA, Alisjahbana B, Dutilh BE, van Crevel R. Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis. BMC Genomics 19:122 (2018)

Stappers MH, Clark AE, Bidula S, Aimanianda V, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace C, Yuecel R, Hebecker B, Teixeira Sousa MG, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NA, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A Jr, Carvalho A, Willment JA, Latgé JP, Brown GD. Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature 555(7696):382-386 (2018)


Babo PS, Pires RL, Santos L, Franco A, Rodrigues F, Leonor I, Reis RL, Gomes ME. Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology. ACS Biomaterials Science and Engineering 3(7):1359-1369 (2017)

Carvalho A, GoldmanGH.Editorial: An Omics Perspective on Fungal Infection: Toward Next-Generation Diagnosis and Therapy. Frontiers in Microbiology 8:85 (2017)

Castela A,Gomes P, Silvestre R, Guardão L, Leite L, Chilro R, Rodrigues I,Vendeira P, Virag R, Costa C. Vasculogenesis and Diabetic Erectile Dysfunction:How Relevant Is Glycemic Control? Journal of Cellular Biochemistry 118(1):82-91 (2017)

Correia CR, Gaifem J, Oliveira MB, Silvestre R, Mano JF. The influence of surface modified poly(l-lactic acid)films on the differentiation of human monocytes into macrophages. Biomaterials Science 5(3):551-560 (2017)

Costa M, Cerqueira MT, Santos TC, Sampaio-Marques BLudovico P, Marques AP, Pirraco RP, Reis RL. Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy. Acta Biomaterialia 55:131-143 (2017)

Cunha C, Gonçalves SM, Duarte-Oliveira C, Leite L,Lagrou K, Marques A,Lupiañez CB, Mesquita I, Gaifem J, Barbosa AM,Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Lass-Flörl C, Löffler J, Jurado M, Saraiva M, Kurzai O, Rodrigues F, Castro AG, Silvestre R, Sainz J, Maertens JA, Torrado E,Jacobsen ID, Lacerda JF, Campos Jr A, Carvalho A. IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity.Journal of Allergy and Clinical Immunology 140(3):867-870.e9 (2017)

De Trizio A, Srisuk P, Costa RR, Fraga AG,Modena T, Genta I, Dorati R, Pedrosa J, Conti B, Correlo VM, Reis RL. Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin. Reactive and Functional Polymers 114:38-48 (2017)

Duarte-Oliveira C, Rodrigues F, Gonçalves SM, Goldman GH, Carvalho A, Cunha C. The Cell Biology of the Trichosporon-Host Interaction. Frontiers in Cellular and Infection Microbiology 7:118 (2017)

Fernandes FF, Oliveira AF, Landgraf TN, Cunha C,Carvalho A, Vendruscolo PE, Gonçales RA, Almeida F, da Silva TA, Rodrigues F, Roque-Barreira MC. Impactof Paracoccin Gene Silencing on Paracoccidioidesbrasiliensis Virulence. mBio 8(4)e00537-17 (2017)

Gonçalves SM, Lagrou K, Duarte-Oliveira C, Maertens JA, Cunha CCarvalho A. The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungaldiseases. Virulence8(6):673-684 (2017)

Gonçalves SM, Lagrou K, Rodrigues CSCampos CF, Bernal-Martínez L, Rodrigues FSilvestre R, Alcazar-Fuoli L, Maertens JA, Cunha CCarvalho A.Evaluation of bronchoalveolar lavage fluid cytokines as biomarkers for invasive pulmonary aspergillosis in at-risk patients. Frontiers in Microbiology 8:2362 (2017)

Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers W,Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.The absence of NOD1 enhanceskilling of Aspergillus fumigatus through modulationof dectin-1 expression.Frontiers in Immunology 8:1777 (2017)

GuedesA, Ludovico P, Sampaio-Marques B. Caloric restriction alleviates alpha-synuclein toxicity in aged yeastcells by controlling the opposite roles of Tor1 and Sir2 on autophagy. Mechanisms of Ageing andDevelopment 161(Pt B):270-276 (2017)

Lind AL,Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F,Goldman GH, Rokas A. Drivers of genetic diversity in secondary metabolic geneclusters within a fungal species. PLOS Biology15(11):e2003583 (2017)

Ludovico P, Côrte-Real M.Yeaston the corner of life and death decisions. Mechanisms of Ageing and Development161(Pt B):199-200 (2017)

Moukambi F,Rodrigues V,Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. CD4 T Follicular Helper Cells and HIV Infection:Friends or Enemies? Frontiers in Immunology 8:135 (2017)

ResendeM, Cardoso MS,Ribeiro AR, Flórido M, Borges M, Castro AG, Alves NL, Cooper AM, Appelberg R.Innate IFN-γ-Producing cells developing in the absence of IL-2 receptor commonγ-chain. Journalof Immunology 199(4):1429-1439 (2017)

Silva EM,Mariano VS, Pastrez PRA, Pinto MC, Castro AG, Syrjanen KJ, Longatto-Filho A. High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PLOS One 12(7):e0181125 (2017)

Vanaerschot M, Lucantoni L, LiT, Combrinck J, Ruecker A, Kumar TR, Rubiano K, Ferreira PE, Siciliano G,Gulati S, Henrich P, Ng C, Murithi J, Corey V, Duffy S,Lieberman O, Veiga MI,Sinden R, Alano P, Delves M, Sim KL, Winzeler E, Egan T, Hoffman SL, Avery V,Fidock D. Hexahydroquinolines are Antimalarial Candidates with Potent Blood Stage and Transmission-Blocking Activity. Nature Microbiology 2(10):1403-1414(2017)

Vriens K,Kumar PT, Struyfs C,Cool TL, Spincemaille P, Kokalj T, Sampaio-Marques B, Ludovico P, Lammertyn J,Cammue BPA, Thevissen K. Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway. Oxidative Medicine and Cellular Longevity 4064628 (2017)


Arts RJ, Carvalho A, La Rocca C, Palma C, Rodrigues FSilvestre R, Kleinnijenhuis J, Lachmandas E, Gonçalves LG, Belinha ACunha C, Oosting M, Joosten LA, Matarese G, van Crevel R, Netea MG. Immunometabolic Pathways in BCG-Induced Trained Immunity. CellReports 17(10):2562-2571(2016)

Arts RJ, Novakovic B, ter Horst R, Carvalho A,Bekkering S, Lachmandas E, Rodrigues FSilvestre R,Cheng SC,Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, vanLaarhoven A, van deVeerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA,Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA,Stunnenberg HG,Xavier RJ, Netea MG. Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity. Cell Metabolism 24(6):807-819 (2016)

Capela C, Dossou AD, Silva-Gomes R, Sopoh GE,Makoutode M, Menino JF, Fraga AGCunha CCarvalho A, Rodrigues F, Pedrosa J. Genetic variation in autophagy-related genes influences the risk and phenotype of Buruli ulcer. PLOS Neglected Tropical Diseases 10(4):e0004671(2016)

Carpenter SM, Nunes-Alves C, Booty MG, Way SS, Behar SM. A Higher Activation Threshold of Memory CD8+ TCells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis. PLOSPathogens 12(1):e1005380 (2016)

Carvalho AL, Vale AC, Sousa MP, Barbosa AMTorrado E, Mano JF, Alves NM. Antibacterial bioadhesive layer-by-layer coatings for orthopedic applications. Journal of Materials Chemistry B4(32):5385-5393(2016)

Chorny A, Casas-Recasens S,Sintes J, Shan M, Polentarutti N,García-Escudero R, Walland AC, Yeiser JR,Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A,Blander JM, Mantovani A, Garlanda C, Cerutti A. The soluble pattern recognition receptor PTX3 linkshumoral innate and adaptive immune responses by helping marginal zone Bcells. Journal of Experimental Medicine 213(10):2167-2185 (2016)

Cordeiro da Costa J, Baia L, Gaio R, Oliveira O, Correia-Neves M, Duarte R. Prevalence and factors associated to Diabetes mellitus among Tuberculosispatients – Anationwide cohort. European Respiratory Journal 48(1):264-268 (2016)

Farhat MR,Sultana R, Iartchouk O, Bozeman S, Galagan J, Sisk P, Stolte C, Nebenzahl-Guimaraes H, Jacobson K,Sloutsky A, Kaur D, Posey J, Kreiswirth BN, Kurepina N,Rigouts L, Streicher EM, Victor TC, Warren RM, van Soolingen D, Murray M.Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value. American Journal of Respiratory and Critical Care Medicine 194(5):621-630 (2016)

Klionsky DJ, Abdelmohsen, K,(…), Ludovico P, (…) Zorzano A,Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222 (2016)

Laforge M, Rodrigues V, Silvestre R, Gautier C,Weil R, Corti O, Estaquier J. NF-κB pathway controls mitochondrial dynamics. Cell Death and Differentiation 23(1):89-98 (2016)

Lupiañez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M,Segura-Catena J, Comino A, Olmedo C, Ríos R,Fernandez-Montoya A,Cuenca-Estrella M, Solano C, López-Nevot MA, Cunha COliveira-Coelho A,Villaescusa T, Fianchi L, Aguado JM,Pagano L, López-Fernández E, Potenza L,Luppi M, Lass-Flörl C, Löffler J,Einsele H, Vázquez L, PCRAGA Study Group,Jurado M, Sainz J. Polymorphisms in host immunity modulating genes and risk of invasive aspergillosis: results from the aspBIOmics consortium. Infection and Immunity 84(3):643-657 (2016)

Mesquita I, Varela P, Belinha A,Gaifem J, Laforge M, Vergnes B, Estaquier J, Silvestre R.Exploring NAD+metabolism in host-pathogen interactions. Cellular and Molecular LifeSciences 73(6):1225-1236(2016)

Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+monitoring in Plasmodium falciparum using the yellow cameleon-Nanobiosensor. ScientificReports 6:23454 (2016)

Pérez-Cabezas B, Cecílio P, Robalo A, Silvestre R, Carrillo E, Moreno J, San Martín JV, Vasconcellos R and Cordeiro-da-Silva A. Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans. Frontiersin Immunology 7:478 (2016)

Silva JP, Gonçalves C, Costa C, Sousa J, Silva-Gomes R, Castro AG, Pedrosa J, Appelberg R, Gama FM. Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment. Journal of Controlled Release 235:112-124 (2016

Veiga MI, Dhingra SK, Henrich PP, Straimer J,Gnädig N, Uhlemann AC, Martin RE, Lehane AM, Fidock DA. Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies. Nature Communications 7:11553 (2016)

Yruela I,Contreras-Moreira B, Magalhães COsório NS,Gonzalo-Asensio J. Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition. Genome Biology and Evolution 8(12):3751-3764 (2016)


Appelberg R, Moreira D, Barreira-Silva P, Borges M, Silva L, Dinis-Oliveira RJ, Resende M, Correia-Neves M, Jordan M, Ferreira N, Abrunhosa A, Silvestre R. The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by gamma interferon. Immunology 145(4):498-507 (2015)

Bruchfeld J, Correia-Neves M, Källenius G. Tuberculosis and HIV coinfection. Cold Spring Harbor Perspectives in Medicine 5(7):a017871 (2015)

Capela C,Sopoh GE, Houezo JG, Fiodessihoué R, Dossou AD, Costa P, Fraga AG, Menino JF,Silva-Gomes R, Ouendo EM, Rodrigues F, Pedrosa J. Clinical epidemiology of Buruli ulcer from Benin(2005-2013): effect of time-delay to diagnosis on clinical forms and severe phenotypes. PLOS Neglected TropicalDiseases 9(9):e0004005 (2015)

Cardoso F, Castro F, Moreira-Teixeira L, Sousa J, Torrado E,Silvestre R, Castro AG, Saraiva M, Pais TF. Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. PLOS One 10(7):e0131904 (2015)

Cardoso MS,Silva TM, Resende M, Appelberg R, Borges M. Lack of the transcription factor hypoxia-inducible factor(HIF)-1α in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas. Infection and Immunity 83(9):3534-3544 (2015)

Carvalho A, Costa P, Triunfante V, Branca F, Rodrigues F, Santos CL, Correia-Neves M, Saraiva M, Lecour H, Castro AG, Pedrosa J, Osório NSAnalysis of a local HIV-1 epidemic in Portugal highlights established transmission of non-Band non-G subtypes. Journal of Clinical Microbiology 53(5):1506-1514 (2015)

Costa I, Carvalho F, Magalhães T, Pinho PG, Silvestre R, Dinis-Oliveira RJ. Promising blood-derived biomarkers for estimation of the postmortem interval. Toxicology Research 4(6):1443-1452 (2015)

Cruz A,Torrado E, Carmona J, Fraga AG, Costa P, Rodrigues F, Appelberg R, Correia-Neves M, Cooper AM, Saraiva M, Pedrosa J, Castro AG. BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells. Vaccine 33(1):85-91 (2015)

Cunha C, Monteiro AA, Oliveira-Coelho A,Kühne J, Rodrigues F, Sasaki SD, Schio SM, Camargo JJ, Mantovani A, Carvalho A, Pasqualotto AC. PTX3-based genetic testing for risk of aspergillosis after lung transplant. Clinical Infectious Diseases 61(12):1893-1894 (2015

Fernandes Â, Azevedo MM, Pereira O, Sampaio-Marques B, Paiva A, Correia-Neves MCastro I, Ludovico P. Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemiatherapeutic approaches. Oncotarget 6(31):31428-31440 (2015)

Garcia J,Costa VM, Carvalho AT, Silvestre R, Duarte JA, Dourado DF, Arbo MD,Baltazar T, Dinis-Oliveira RJ, Baptista P, de Lourdes Bastos M, Carvalho F. A breakthrough on Amanita phalloides poisoning: an effective antidotal effect bypolymyxin B. ArchivesofToxicology 89(12):2305-2323 (2015)

Gomes V, Pala M, Salas A, Álvarez-Iglesias V, Amorim A,Gómez-Carballa A, Carracedo Á, Clarke DJ, Hill C, Mormina M, Shaw MA, Dunne DW, Pereira R, Pereira V, Prata MJ, Sánchez-Diz P, Rito T, Soares P, Gusmão L, Richards MB. Mosaic maternal ancestry in the Great Lakes region of East Africa. Human Genetics 134(9):1013-1027 (2015)

Janganan TK, Chen G, Chen D, Menino JFRodrigues F,Borges-Walmsley MI, Walmsley AR. A Gβ protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to Act as Antagonistic Molecular Switches of Fungal Morphological Changes. PLOS One 10(9):e0136866(2015)

LopesSantos C, Nebenzahl-Guimaraes H, Mendes MV, van Soolingen D, Correia-Neves M. To Be or Not to Be a Pseudogene: A Molecular Epidemiological Approach to the mclx Genes and Its Impact in Tuberculosis. PLOS One 10(6):e0128983 (2015)

Moukambi F,Rabezanahary H, Rodrigues V, Racine G, Robitaille L, Krust B, Andreani G, Soundaramourty C, Silvestre R, Laforge M, Estaquier J. Early loss of splenic Tfh cells in SIV-infected rhesus macaques. PLOS Pathogens 11(12):e1005287 (2015)

Nebenzahl-Guimaraes H, Verhagen LM,Borgdorff MW, van Soolingen D. Transmission and Progression to Disease of Mycobacterium tuberculosis Phylogenetic Lineages in The Netherlands. Journal of Clinical Microbiology 53(10):3264-3271 (2015)

Nunes-Alves C, Booty MG, Carpenter S, Rothchild AC, Martin CJ, Desjardins D, Steblenko K,Kløverpris HN, Madansein R, Ramsuran D, Leslie A, Correia-Neves M,Behar SM. Human and murineclonal CD8+ T cell expansions arise during tuberculosis because of TCR selection. PLOS Pathogens 11(5):e1004849 (2015)

Oliveira-Coelho A, Rodrigues F, Campos Jr. A, Lacerda JF, Carvalho A, Cunha C. Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis. Frontiers In Microbiology 6:411 (2015)

Santos J, Leitão-Correia F, Sousa MJ, LeãoC. Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium. Oncotarget 6(9):6511-6523 (2015)

Silva-Gomes R, Marcq E, Trigo G, Gonçalves CM, Longatto-Filho A, Castro AG, Pedrosa J, Fraga AG. Spontaneous healing of Mycobacterium ulcerans lesions in the guinea pig model. PLOS Neglected Tropical Diseases 9(12):e0004265 (2015)


Colabardini AC, Ries LN, Brown NA, Dos Reis TF, Savoldi M, Goldman MH, Menino JF, Rodrigues F, Goldman GH. Functional characterization of a xylose transporter in Aspergillus nidulans. Biotechnology of Biofuels 7:46 (2014)

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O,Grube M, Loffler J,Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B,Sousa PSE, Barbui A,Potenza L, Caira M, Rodrigues F, Salvatori G,Pagano L, Luppi M, Mantovani A,Velardi A, Romani L, Carvalho A.Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation. The New England Journal of Medicine 370(5):421-432 (2014)

Cunha C, Kurzai O, Löffler J, Aversa F,Romani L, Carvalho A. Neutrophil responses to aspergillosis: new roles for old players. Mycopathologia 178(5-6):387-393 (2014)

Fernandes E, Martins VC, Nóbrega C, Carvalho CM, Cardoso FA,Cardoso S, Dias J, Deng D, Kluskens LD, Freitas PP, Azeredo J. A bacteriophage detection tool for viability assessment of Salmonella cells. Biosensors and Bioelectronics 52:239-246 (2014)

Gabryšová L, Howes A, Saraiva M, O'Garra A. The Regulation of IL-10 Expression. Interleukin-10 in Health and Disease: Current Topics in Microbiology and Immunology 380:157-190 (2014)

Gama JB,Ohlmeier S, Martins TG, Fraga AG, Sampaio-Marques B, Carvalho MA,Proenca F , Silva MT, Pedrosa J, Ludovico P. Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen. PLOS Neglected Tropical Diseases 8(8):e3066 (2014)

Jovel IT, Ferreira PE, Veiga MI, Malmberg M, MårtenssonA, Kaneko A, Zakeri S, Murillo C, Nosten F, Björkman A, Ursing J. Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms. Infection, Genetics and Evolution 24:111-115 (2014)

Ludovico P, Burhans WC.Reactive oxygen species, ageing and the hormesis police. FEMS Yeast Research 14(1):33-39 (2014)

McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N,Saraiva M, O'Garra A. Type I IFN Induces IL-10 Production in anIL-27–Independent Manner and Blocks Responsiveness to IFN-g for Production ofIL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages. The Journal of Immunology 193(7):3600-3612 (2014)

Mesquita SD,Ferreira AC, Falcao AM, Sousa JC, OliveiraTG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid beta. Cell Death and Differentiation 21(10):1588-1599 (2014)

Mira NP,Münsterkötter M, Dias-Valada F, Santos J, Palma M, Roque FC,Guerreiro JF, Rodrigues F, Sousa MJ, Leão C,Güldener U, Sá-Correia I. The Genome Sequence of the Highly Acetic Acid-Tolerant Zygosaccharomyces bailii-Derived Interspecies Hybrid Strain ISA1307, Isolated From a Sparkling Wine Plant. DNA Research 21(3):299-313 (2014)

Moiane I, Machado A, Santos N,Nhambir A, Inlamea O, Hattendorf J, Kallenius G, Zinsstag J, Correia-Neves M. Prevalence of Bovine Tuberculosis and Risk Factor Assessment in Cattle in Rural Livestock Areas of Govuro District in the Southeast of Mozambique. PLOS One 9(3):e91527 (2014)

Nebenzahl-Guimaraes H, Borgdorff MW,Murray MB, van Soolingen D. A Novel Approach - The Propensity to Propagate(PTP) Method for Controlling for Host Factors in Studying the Transmission of Mycobacterium Tuberculosis. PLOS One 9(5):e97816 (2014)

Nebenzahl-Guimaraes H, Jacobson KR,Farhat MR, Murray MB. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacteriumtuberculosis. Journal of Antimicrobial Chemotherapy 69(2):331-342 (2014)

Nunes-Alves C, Booty MG,Carpenter SM, Jayaraman P, Rothchild AC, Behar SM. In search of a new paradigm for protective immunity to TB.Nature Reviews Microbiology 12(4):289-299 (2014)

Roque S,Mesquita AR, Palha JA, Sousa N, Correia-Neves M. The behavioral and immunological impact of maternal separation: a matter of timing. Frontiers in Behavioral Neuroscience 8:192 (2014)

Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT Cell Production of GM- CSF Controls Mycobacterium tuberculosis. PLOS Pathogens 10(1):e1003805 (2014)

Teixeira-Coelho M, Guedes J, Ferreirinha P, Howes A, Pedrosa J, Rodrigues F, Lai WS, Blackshear PJ, O'Garra A, Castro AG, Saraiva M. Differential post-transcriptional regulation of IL-10 by TLR2and TLR4-activated macrophages. European Journal of Immunology 44(3):856-866 (2014)

Veiga MI, Osório NS, Ferreira PE, Franzén O,Dahlstrom S, Lum JK, Nosten F, Gil JP. Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response. Antimicrobial Agents and Chemotherapy 58(12):7390-7397(2014)


Afonso-Barroso A, Clark SO, Williams A, Rosa GT, Nóbrega C, Silva-Gomes S,Vale-Costa S, Ummels R, Stoker N, Movahedzadeh F, van der Ley P, Sloots A, CotM, Appelmelk BJ, Puzo G, Nigou J, Geurtsen J, Appelberg R. Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses. Cellular Microbiology 15(4):660-674 (2013)

Andrade EB, Alves J, Madureira P, Oliveira L, Ribeiro A,Cordeiro-da-Silva A, Correia-Neves M, Trieu-Cuot P, Ferreira P.TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. Journal of Immunology 191(9):4759-4768 (2013)

CarmonaJ, Andrea C, Moreira-Teixeira L, Sousa C, Sousa J, Osorio NS, Saraiva AL, Svenson S, Kallenius G, Pedrosa J, Rodrigues F, Castro AG, Saraiva M. Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLOS One 8(6):e67277 (2013)

Guaragnella N, Palermo V, Burhans WC, Gourlay CW, Ludovico P, Madeo F,Giannattasio S, Mazzoni C. Yeast between life and death: a summary of the Ninth International Meeting on Yeast Apoptosis in Rome, Italy, 17-20 September 2012. Cell Death and Differentiation 20(9):1281-1283 (2013)

Horta A, Nobrega C, Amorim-Machado P, Coutinho-Teixeira V, Barreira-Silva P, Boavida S, Costa P, Sarmento-Castro R, Castro AG, Correia-Neves M. Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4(+) T Cells. PLOS One 8(2):e57336(2013)

McNab FW,Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A.TPL-2-ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production. Journal of Immunology 191(4):1732-1743 (2013)

Menino JF, Saraiva M, Gomes-Alves AG, Lobo-Silva D,Sturme M, Gomes-Rezende J, Saraiva AL, Goldman GH, Cunha C,Carvalho A, Romani L,Pedrosa J, Castro AG, Rodrigues F. TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival. PLoS Neglected TropicalDiseases 7(7):e2317 (2013)

Menino JF, Saraiva M, Gomes-Rezende J, Sturme M, Pedrosa J, Castro AG, Ludovico P, Goldman GH, Rodrigues F. P.brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation. PLOS One 8(9):e74725 (2013)

Nóbrega C, Nunes-Alves C, Cerqueira-Rodrigues B, Roque S,Barreira-Silva P, Behar SM, Correia-Neves M. T Cells Home to the Thymus and Control Infection. Journal of Immunology 190(4):1646-1658 (2013)

Nunes-Alves C, Nobrega C, Behar SM, Correia-Neves M. Tolerance has its limits: how the thymus copes with infection. Trends in Immunology 34(10):502-510 (2013)

Osório NS, Rodrigues F,Gagneux S, Pedrosa J, Pinto-Carbó M, Castro AG, Young D, Comas I, Saraiva M. Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic and non-antibiotic related pressure. Molecular Biology and Evolution 30(6):1326-1336 (2013)

Pacheco A, Azevedo F, Rego A, Santos J, Chaves SR, Côrte-Real M, Sousa MJ. C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in asterol-dependent manner. PLOS One 8(9):e74240 (2013)

Sousa M, Duarte AM, Fernandes TR, Chaves SR, Pacheco A, Leão C, Côrte-Real M, Sousa MJ. Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae. BMC Genomics 14:838 (2013)

Trigo G,Martins TG, Fraga AG, Longatto-Filho A, Castro AG, Azeredo J, Pedrosa J. PhageTherapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model. PLOS Neglected Tropical Diseases 7(4):e2183 (2013)

Weinberger M, Sampaio-Marques B, Ludovico P, Burhans WC. DNA replication stress-induced loss of reproductive capacity in S. cerevisiae and its inhibition by caloric restriction. Cell Cycle 12(8):1189-1200 (2013)


Borges M,Barreira-Silva P, Florido M, Jordan MB, Correia-Neves M, Appelberg R. Molecular and Cellular Mechanisms of Mycobacterium avium-lnduced Thymic Atrophy. Journal of lmmunology 189(7):3600-3608 (2012)

Carvalho A,Cunha C, Bistoni F, Romani L. Immunotherapy of aspergillosis. Clinical Microbiology and Infection 18(2):120-125 (2012)

Carvalho A,De Luca A, Bozza S, Cunha C, D' Angelo C, Moretti S, Perruccio K, lannitti RG,Fallarino F, Pierini A, Latge JP, Velardi A, Aversa F, Romani L. TLR3 essentially promotes protective class I-restricted memoryCD8(+) T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Blood 119(4):967-977 (2012)

Costa V,Ludovico P. Yeast as a platform to uncover ceramide-induced ancient cell death routines. Cell Cycle 11(1):14-15 (2012)

Fraga AG,Martins TG, Torrado E, Huygen K, Portaels F, Silva MT, Castro AG, Pedrosa J.Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination. PLOS One 7(3):e33406 (2012)

Franco NH, Correia-Neves M, Olsson IA. How "humane" is your end point?­Refining the science-driven approach for termination of animal studies of chronic infection. PLOS Pathogens 8(1):e1002399 (2012)

lannittiRG, Carvalho A, Romani L. From memory to antifungal vaccine design. Trends in lmmunology 3(9):467-474 (2012)

Luca AD,lannitti RG, Bozza S, Beau R, Casagrande A, D'Angelo C, Moretti S, Cunha C,Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latge JP, Romani L. CD4+ Tcell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease. Journal of Clinical Investigation 122(5):1816-1831 (2012)

Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH, Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N,Correia-Neves M, Palha JA. Lipocalin2 is present in the EAE brain and is modulated by natalizumab. Frontiers in Cellular Neuroscience 6:33 (2012)

Martin CJ,Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM,Remold HG, Behar SM. Efferocytosis Is an Innate Antibacterial Mechanism. Cell Host & Microbe 12(3):289-300 (2012)

Martins TG,Trigo G, Fraga AG, Gama JB, Longatto-Filho A, Saraiva M, Silva MT, Castro AG,Pedrosa J. Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulceransInfection. PLOS Neglected Tropical Diseases6(11):e1925 (2012)

Mesquita SD, Ferreira AC, Sousa JC, Santos NC, Correia-Neves M, Sousa N, Palha JA,Marques F. Modulation of iron metabolism in aging and in Alzheimer's disease:relevance of the choroid plexus. Frontiers in Cellular Neuroscience 6:25 (2012)

Mishra AK,Alves JE, Krumbach K, Nigou J, Castro AG, Geurtsen J, Eggeling L, Saraiva M,Besra GS. Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell Differentiation. Journal of Biological Chemistry 287(53):44173-44178 (2012)

Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS,Outeiro TF, Winderickx J, Ludovico P. SNCA (a-synuclein)­ induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 8(10):1494-1509 (2012)

Veiga Ml,Ferreira PE, Malmberg M, Jornhagen L, Bjorkman A, Nosten F, Gil JP. pfmdr1 amplification is related to increased Plasmodium falciparum in vitrosensitivity to the bisquinoline piperaquine. Antimicrobial Agents and Chemotherapy. 56(7):3615-3619 (2012)

Copyright © 2012-2016 ICVS. All rights reserved.