about icvs | People | SUSANAMONTEIRO


Name: Susana Monteiro

Office: I2.02

School Phone: +351 253 604 839

Email: susanamonteiro@med.uminho.pt




Keywords: Immunomodulation Neuroinflammation Spinal Cord Injury Neuroregeneration


Susana Monteiro (36 years old) is a Junior Researcher in the Neuroscience Research Domain at the Life and Health Sciences Research Institute (ICVS) - University of Minho. She completed her BSc in 2007, her MSc in 2008 and her PhD (Health Sciences - Neuroimmunology) in 2016. Her PhD work identified a new role for  a  proinflammatory cytokine – IFNgamma, in the modulation of hippocampal plasticity and cognitive function with implications for the development of neuropsychiatric disorders. During her scientific training she was involved in multiple projects spanning from a clinical research project searching for new MS biomarkers, to pharmacological projects testing and assessing anti-depressants efficacy and mode of action in pre-clinical rodent models of depression, to basic science projects understanding mechanisms underlying cognitive function.

She is now interested in understanding the neural control of the immune response and how spinal cord injury disrupts physiological neuroimmune interactions. She aims at identifying peripheral targets for immunomodulation and repair of the injured central nervous system. Her research focus both at understanding the contribution of inflammation for secondary injury and designing immunomodulatory strategies to boost repair of the spinal cord after injury.


Sofia P das Neves, Gisela Santos,  Cristina Barros, Diana R Pereira, Ricardo Ferreira, Cristina Mota, Susana Monteiro, Anabela Fernandes, Fernanda Marques, João J Cerqueira (2020) Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms. Journal of Neuroimmunology. Jan 13;340:577163 doi: 10.1016/j.jneuroim.2020.577163.


Cristina Mota, Ricardo Taipa , Sofia das Neves , Sara Monteiro-Martins , Susana Monteiro, Joana Palha , João Sousa , Nuno Sousa, João José Cerqueira (2019) Structural and molecular correlates of cognitive aging in the rat Scientific Reports -  Feb 14;9(1):2005. doi: 10.1038/s41598-019-39645-w. in press

Rui Lima, Susana Monteiro, José P Lopes, Pedro Barradas, Natália L. Vasconcelos, Eduardo Gomes, Rita Assunção-Silva, Fábio Rodrigues-Teixeira, Mónica Morais, Nuno Sousa, António Salgado, Nuno Silva (2017) Systemic Interleukin-4 administration after spinal cord injury modulates inflammation and promotes neuroprotection. Pharmaceuticals 10(4):83.doi:10.3390/ph10040083

Susana Monteiro,Susana Roque, Margarida Correia-Neves, João José Cerqueira: Brain Interference: revisiting the role of IFNgamma in the central nervous system. Progress in Neurobiology, 2017, 156:149-163 09/17 DOI: 10.1016/j.pneurobio.2017.05.00

Novais, A.*, Monteiro, S.*, Roque, S.*, Correia-Neves, M., Sousa, N. 2017. How age, sex and genotype shape the stress response. Neurobiology of stress 6, 44-56. doi:10.1016/j.ynstr.2016.11.004. *equally contributing authors

Susana Monteiro, Filipa M. Ferreira, Vítor Pinto, Susana Roque, Mónica Morais, Daniela de Sá-Calçada, Cristina Mota, Nuno Sousa, Margarida Correia-Neves, João José Cerqueira: Absence of IFNgamma promotes hippocampal plasticity and enhances cognitive performance. Translational Psychiatry. 01/2016 6, e707 doi:10.1038/tp.2015.194

Daniela d. Calçada, Susana Roque, Carlos Branco, Susana Monteiro, Bruno Cerqueira- Rodrigues, Nuno Sousa, Joana A. Palha, Margarida Correia-Neves: Exploring female mice interstrain differences relevant for models of depression. Frontiers in Behavioral Neuroscience. 12/2015 doi: 10.3389/fnbeh.2015.00335

Susana Monteiro, Susana Roque, Daniela de Sá-Calçada, Nuno Sousa, Margarida Correia-Neves, João José Cerqueira: An Efficient Chronic Unpredictable Stress Protocol to Induce Stress-Related Responses in C57BL/6 Mice. Frontiers in Psychiatry 02/2015; 6. DOI:10.3389/fpsyt.2015.00006

A Mateus-Pinheiro, L Pinto, J M Bessa, M Morais, N D Alves, S Monteiro, P Patrício, O F X Almeida, N Sousa: Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Translational Psychiatry 01/2013; 3(1):e210. DOI:10.1038/tp.2012.141

Susana Monteiro and João José Cerqueira: Modo de ação do fingolimod. Sinapse.2012; 12(2) suppl.1 23-29 


The role of the immune system in mood disorders and cognition  

Selected Publications

Monteiro S, Ferreira F, Pinto V, Roque S, Morais M, Sá-Calçada D, Mota C, Correia-Neves M, Cerqueira JJ. Absence of IFN? promotes hippocampal plasticity and enhances cognitive performance. Transl Psychiat, 6:e707 (2016).

Mateus-Pinheiro A, Pinto L, Bessa JM, Morais M, Alves ND, Monteiro S, Patrício P, Almeida OFX and Sousa N. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Transl Psychiatry, 3(1): e210 (2013).

Monteiro S, Roque S, de Sá-Calçada D, Sousa N, Correia-Neves M, Cerqueira JJ. An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL/6 mice. Front Psychiatry, 6:6 (2015).

Monteiro S, Ferreira FM, Pinto V, Roque S, Sá-Calçada D, Morais M, Sousa N, Correia-Neves M, Cerqueira JJ. "Absence of IFNg promotes hippocampal plasticity and enhances cognitive performance". Transl Psychiat. 2016 Jan 5;6:e707.

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