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Name: Patricia Monteiro

Office: I2.10

School Phone: +351 253 604 902

Email: patriciamonteiro@med.uminho.pt

 

 

 

Keywords: Stress OCD Autism neuroscience inhibitory networks transgenic mice electrophysiology optogenetics

About

Patricia Monteiro is a Research assistant professor in the Department of Neuroscience, ICVS/School of Medicine, University of Minho.
She holds a BSc/MSc degree in Pharmaceutical Sciences and a PhD degree in Neuroscience.

Dr. Monteiro did her Ph.D. training with Prof. Guoping Feng at the Massachusetts Institute of Technology (MIT, USA), where she focused on understanding brain circuitry mechanisms underlying repetitive behaviors present in obsessive-compulsive (OCD) and autism-spectrum disorders (ASD). She published a study showing reversal of autistic-like behaviors in adult mice by restoring the Shank3 gene [Nature, 2016] and coauthored another publication showing that particular human mutations in the Shank3 gene can lead to distinct neuropsychiatric disorders [Neuron, 2016]. Later, as an EMBO postdoctoral fellow, she worked with Prof. Nuno Sousa at ICVS University of Minho studying chronic stress. She also collaborated with Dr. Ann Graybiel (MIT, USA) in a study where optogenetic stimulation of orbitofronto-striatal pathway was used to cut off compulsive behaviors in mice [Science, 2013].
Dr. Monteiro's lab focuses on interneurons function in neurodevelopmental and neuropsychiatric disorders, using in vivo and patch clamp electrophysiology.


The stressed brain project (Society in Science):

https://brancoweissfellowship.org/fellow/monteiro.html


In the News:

National Geographic: Making and Breaking Compulsive Behaviour

The MIT news: Neuroscientists reverse autism symptoms

Expresso: Passeio Público - Patrícia Monteiro[interview in portuguese]


Author IDs:

Scopus Author ID: 55759186000
ResearcherID: Q-7646-2017
ORCID ID: 0000-0003-3288-4560


Recent publications:

Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, and Feng G. Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum.
The Journal of Physiology 596: 3695-3707. 2018.

Monteiro P. Shank3 mutations and HCN channelopathy: one size does not fit all.
The Journal of Physiology 596(7):1123. 2018.

Monteiro P. and Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder.
Nature Reviews Neuroscience 18(3):147-157. 2017.

Mei Y*, Monteiro P*, Zhou Y, Kim J, Gao X, Fu Z, and Feng G. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Nature 530(7591):481-4. 2016.
*These authors contributed equally to this work..

Zhou Y, Kaiser T*, Monteiro P*, Zhang X*,  Van der Goes MS, Wang D, Barak B, Zeng M, LiC, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G. Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects.
Neuron 89:147-162. 2016. *These authors contributed equally to this work.

Zhang Q*, Gao X*, Li C*, Feliciano C, Wang D, Zhou D, Mei Y, Monteiro P, Anand M, Itohara S, Dong X, Fu Z, Feng G. Impaired dendritic development and memory in Sorbs2 knockout mice.
The Journal of Neuroscience 17;36(7):2247-60. 2016. *These authors contributed equally to this work.

Monteiro P and Feng G. Learning from Animal Models of Obsessive-Compulsive Disorder.
Biological Psychiatry
79(1):7-16. 2016.


Burguière E, Monteiro P, Feng G and Graybiel AM. Striatal circuits, habits, and implications for obsessive-compulsive disorder.

Current Opinion in Neurobiology 30:59-65. 2015.

Kaiser T*, Ting J*, Monteiro P and Feng G. Transgenic labeling of parvalbumin-expressing neurons with tdTomato.
Neuroscience 3;321:236-45. 2015. *These authors contributed equally to this work.

Burguière E, Monteiro P, Feng G and Graybiel AM. Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. 
Science 340(6137):1243-6. 2013.

Gomes JR*, Costa JT*, Melo CV, Felizzi F, Monteiro P, Pinto MJ, Inácio AR, Wieloch T, Almeida RD, Grãos M, Duarte CB. Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.
The Journal of Neuroscience 32(13):4610-22. 2012. *These authors contributed equally to this work.


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