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about icvs | People | FABIOTEIXEIRA

 

Name: Fábio Teixeira

Office: G2.25

School Phone: +351 253 604 929

Email: fabioteixeira@med.uminho.pt

 

 

 

Keywords: Regenerative Medicine Mesenchymal Stem Cells Stem Cells Secretome Bioreactor Cell Culture Exosomes Astrocyte reactivity Neuron-glia communication 3D culture systems Parkinson's Disease

About

From 2010 to 2015 I did my PhD in Health Sciences at the Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho. During such period, I was also a visiting PhD student at the Pharmaceutical Production Research Facility (PPRF), University of Calgary, Canada. In February of 2015, I started a post-doctoral position at ICVS exploring the combinatorial potential of stem cells secretome (SCS) and (neuroprotective/disease-modifying) pharmacological strategies for the regenerative treatment of Parkinson's disease (PD). During my post-doc, I showed SCS as a promising therapeutic tool for the establishment of regenerative or adjuvant strategies to PD modeling and repair, by identifying potential (PD) molecules present in SCS, as well as potential associated mechanisms that impacted the dopaminergic system with significant impact on dopaminergic neuronal cell survival and behavior. These innovative concepts on SCS and pharmacotherapies were awarded approximately 440K in competitive calls in which I am the Principal Investigator. Such funds allow me to start creating my own research group.

Currently, as an Assistant Researcher, my research program includes the supervision of a Post-doctoral fellow and 1 MSc student, aiming to understand how SCS interacts with potential neuroprotective PD drugs, and how they impact PD neurodegenerative processes and circuits. 

Simultaneously, I have also been involved in multiple research teams/projects successfully funded, which have been creating a strong impact in the field of stem cells and (CNS) regenerative medicine. Still, I have also been involved in advanced training, lecturing annually in three post-graduation courses (e.g. Fundamentals in Neuroscience, Pathogenesis of Neurodegenerative Diseases and Bioinformatics in Health Sciences), and in lab management, as I currently am the Head of the ICVS Cell Culture Facilities. In addition, I have also been involved in the organization of scientific meetings, as the 1st International Symposium Secretome With]Out[Borders that was held in ICVS.

Projects

Exploring the Therapeutic Potential of the Secretome of Mesenchymal Stem Cells in CNS Regenerative Medicine  

Selected Publications

Teixeira FG, Carvalho MM, Sousa N, Salgado AJ. Mesenchymal Stem Cells Secretome: a new paradigm for Central Nervous System Regeneration? Cell Mol Life Sci. 2013 Oct;70(20):3871-82. doi: 10.1007/s00018-013-1290-8. Epub 2013 Mar 1.

Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

Teixeira FG*, Panchalingam KM*, Anjo Si, Manadas B, Pereira R, Sousa N, Salgado AJ**, Behie LA**. Do Hypoxia/Normoxia Culturing Conditions Change the Neuroregulatory Profile of Wharton Jelly Mesenchymal Stem Cells Secretome?. Stem Cell Res Ther, 6(1):133 (2015).

Carvalho MM, Teixeira FG, Reis RL, Sousa N, Salgado AJ. Mesenchymal stem cells in the umbilical cord: phenotypic characterization, secretome and applications in central nervous system regenerative medicine. Curr Stem Cell Res Ther. 2011 Sep;6(3):221-8.

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