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Name: Ana Mendanha Falcão

Office: I2.13

School Phone: +351 253 604 875

Email: amfalcao@med.uminho.pt

 

 

 

Keywords: choroid plexus multiple sclerosis oligodendrocytes

About

Ana Mendanha Falcão has recently started her research team supported by the la caixa junior leader fellowship. She is studying the functions of the choroid plexus (CP), an overlooked tissue whose most described function is the production of the cerebrospinal fluid (CSF).

During her PhD she have gained expertise in the CP and on the adult neural stem and progenitor cells of the subependymal zone. Then, she moved to Karolinksa Institutet where she has participated and developed research projects focused on oligodendrocyte (OL) cell biology and multiple sclerosis (MS) that have significantly changed the view of OL heterogeneity and OL role in MS pathology. These findings were published in the peer-review journals Science, Nature Medicine, Cell Reports and Nature, and have been disseminated worldwide.

The projects Ana Falcão is developing now result from a combination of her expertise acquired so far, and bridge three main themes together: choroid plexus biological functions, oligodendrocyte cell biology and multiple sclerosis etiology/pathology.

Click here for publications

Key publications:

Falcao, A. M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S. C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A., Ernfors, P., Castro, D. S., Nielsen, M. L., Casaccia, P., and Castelo-Branco, G. (2019) PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Rep 27, 1090-1102 e1010


Jakel, S., Agirre, E., Falcao, A.M., van Bruggen, D., Lee, K. W., Knuesel, I., Malhotra, D., Ffrench-Constant, C., Williams, A., and Castelo-Branco, G. (2019) Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature 566, 543-547


Falcao, A. M., van Bruggen, D., Marques, S., Meijer, M., Jakel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., Ffrench-Constant, C., Williams, A., Guerreiro-Cacais, A. O., and Castelo-Branco, G. (2018) Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis. Nat Med 24, 1837-1844


Falcao, A. M., Marques, F., Novais, A., Sousa, N., Palha, J. A., and Sousa, J. C. (2012) The path from the choroid plexus to the subventricular zone: go with the flow! Frontiers in Cellular Neuroscience 6

Awards:


2019 - Awarded VR starting grant within medicine and  health 

2019 - Awarded Junior Leader Fellowship grant from “la caixa”

2015 - Postdoctoral Research Fellowship awarded by The European Committee for Treatment and Research in Multiple Sclerosis ECTRIMS



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