about icvs | People | AGOSTINHOCARVALHO


Name: Agostinho Carvalho

Office: I3.05

School Phone: +351 253 604 811

Email: agostinhocarvalho@med.uminho.pt




Keywords: Fungal Disease Host Genetics Immunity Host-Pathogen Interaction Stem-Cell Transplantation Personalized Medicine


Agostinho Carvalho is a biologist and received his PhD in Health Sciences– Biological and Biomedical Sciences, from the University of Minho in 2008. His PhD work focussed on interpreting the contribution of genetic variation in innate immunity to susceptibility to fungal diseases. Between 2009 and 2012, he was a Postdoctoral research fellow at the University of Perugia, Italy (in collaboration with ICVS/3B’s) and his research consisted on resolving the molecular and cellular mechanisms by which genetic variation of innate immunity dictated susceptibility to fungal disease. In 2012, he was selected in an international call for a PhD researcher position and acted as a faculty member of the Department of Experimental Medicine of the University of Perugia until 2014. Currently, he is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. His research interests are focussed on the dissection of the genetic architecture of antifungal immunity regulation and its role in susceptibility to fungal disease, particularly in immunocompromised hosts. These aims are being addressed in the lab by resorting to advanced cellular and animal models of fungal infection and by investigating human patients suffering from fungal disease enrolled in national and international consortia.


Selected Publications

Arts RJ, Novakovic B, ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG. “Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity”. Cell Metab. 24(6):807-19 (2016).

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A. “The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells”. J Exp Med. 213(10):2167-85 (2016).

De Luca A, Iannitti RG, Bozza S, Beau R, Casagrande A, D'Angelo C, Moretti S, Cunha C, Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latgé JP, Romani L. CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease. J Clin Invest. 2012 May 1;122(5):1816-31. doi: 10.1172/JCI60862. Epub 2012 Apr 23.

Iannitti RG1, Carvalho A, Romani L. From memory to antifungal vaccine design. Trends Immunol. 2012 Sep;33(9):467-74. doi: 10.1016/j.it.2012.04.008. Epub 2012 May 28.

Carvalho A, De Luca A, Bozza S, Cunha C, D'Angelo C, Moretti S, Perruccio K, Iannitti RG, Fallarino F, Pierini A, Latgé JP, Velardi A, Aversa F, Romani L.TLR3 essentially promotes protective class I-restricted memory CD8? T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Blood. 2012 Jan 26;119(4):967-77. doi: 10.1182/blood-2011-06-362582. Epub 2011 Dec 6.

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